BEIRUT — A drone strike early Sunday that killed three U.S. service members and wounded dozens more is threatening to upend the Biden administration’s delicate effort to prevent the Israel-Hamas war from spiraling into a broader regional conflict or direct confrontation with Iran.

In the more than three months since Hamas killed 1,139 Israelis in a surprise attack and Israel responded with a punishing invasion into the Gaza Strip that has left about 27,000 dead, President Joe Biden has tried to keep hostilities from spreading in the restive region.

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